反应详情

温度

80 °C

Ethyl 4-bromo-3-hydroxybenzoate (200 mg) was dissolved in DMF (10 ml) and 4-iodo-butyl acetate (195 μl) and sodium hydride (56 mg, 60% dispersion in mineral oil) were added and the reaction stirred at 80° C. under nitrogen for 3 hours. The reaction was quenched with water (5 ml) and the solvents evaporated under vacuum. The residue was partitioned between ethyl acetate/chloroform (1:1) and water. The organic phase was dried using a hydrophobic filter and the solvent evaporated in vacuo to give ethyl 3-{[4-(acetyloxy)butyl]oxy}-4-bromobenzoate as a yellow gel (318 mg).

1. customThe reaction was quenched with water (5 ml)
2. customthe solvents evaporated under vacuum
3. customThe residue was partitioned between ethyl acetate/chloroform (1:1) and water
4. customThe organic phase was dried
5. filtrationa hydrophobic filter
6. customthe solvent evaporated in vacuo