Oxalyl chloride → Phenethyloxy-acetyl chloride

HRID 2100467Notes

Reaction equation

HRID 2100467 reaction equation
[CH2:1]([O:9][CH2:10][C:11]([OH:13])=O)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(Cl)(=O)C([Cl:17])=O>ClCCl.CN(C=O)C>[CH2:1]([O:9][CH2:10][C:11]([Cl:17])=[O:13])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 13208922(2-Phenylethoxy)acetic acid

Product 1

HCID 19593432Phenethyloxy-acetyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

Phenethyloxy-acetic acid (3.89 g, 18.9 mmol) was dissolved in a mixture of 50 ml dichloromethane and 2.6 ml DMF. Oxalyl chloride ([79-37-8], 1.76 ml, 20.8 mmol) was slowly added, and the mixture was stirred at r.t. overnight. Phenethyloxy-acetyl chloride [221019-38-1] was obtained after evaporation of the solvent, and was sufficiently pure for the next step.

Sources & evidence

ORD record
ord-13055632fcda459d81e58fa20a2966dd
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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