反应详情

To a solution of 2-chloro-5-(trifluoromethyl)benzoic acid (15 g, 66.8 mmol) in methylene chloride (200 mL) was added oxalyl chloride (12.7 g, 100 mmol) drop wise followed by the addition of 5-6 drops of DMF. The reaction mixture was concentrated, the residue partitioned between methylene chloride and 5% aq. sodium carbonate. The organic layer was dried (MgSO4) and concentrated to give the title compound as a pale oil (16 g).

1. concentrationThe reaction mixture was concentrated
2. customthe residue partitioned between methylene chloride and 5% aq. sodium carbonate
3. dry with materialThe organic layer was dried (MgSO4)
4. concentrationconcentrated