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HRID2100676

反应详情

EQUATION

反应方程式

HRID 2100676 的结构方程式

REACTANTS

反应物

4
结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：FC(F)(F)c1cc(CCl)ccc1Cl
HCID13094262

1-Chloro-4-(chloromethyl)-2-(trifluoromethyl)benzene

C8H5Cl2F3

结构：CC(C)(C)OC(=O)N1CCC(c2ccc(O)cc2)CC1
HCID19381871

tert-Butyl 4-(4-hydroxyphenyl)piperidine-1-carboxylate

C16H23NO3

结构：CCCCCC.CCOC(C)=O
HCID21226206

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC(c2ccc(OCc3ccc(Cl)c(C(F)(F)F)c3)cc2)CC1
HCID68813008

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

PROCEDURE

实验过程

To a solution of 4-(4-hydroxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (1 eq) in anhydrous DMF is added NaH (1.1 eq) at room temperature. After 5 minutes, 1-chloro-4-chloromethyl-2-trifluoromethyl-benzene (1.1 eq) in DMF is added. The resulting mixture is stirred for 30 minutes. After aqueous work up, flash column chromatography (10% EtOAc/hexane) gave 4-[4-(4-Chloro-3-trifluoromethyl-benzyloxy)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester. [MS: (ES+) 490.3 (M+1)+].