Hydrochloric Acid → HCID 76608725, compound

HRID 2100739Notes

Reaction equation

HRID 2100739 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][C:14]=1[O:15][CH2:16][CH2:17][O:18][CH3:19])[C:11](=[O:20])[CH2:10][CH2:9]2.C([O:25][N:26]=O)CCC.Cl>CO>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][C:14]=1[O:15][CH2:16][CH2:17][O:18][CH3:19])[C:11](=[O:20])[C:10](=[N:26][OH:25])[CH2:9]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10996Butyl nitriteHCID 57799839HCID 57799839, compound

Product 1

HCID 76608725HCID 76608725, compoundYield 38.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 5,6-Bis-(2-methoxy-ethoxy)-indan-1-one (2.6 g, 9.28 mmol) in the methanol (20 ml) was added n-butylnitrite (1.25 ml, 10.2 mmol) followed by concentrated HCl (0.8 ml). The solution was stirred at room temperature overnight during which time a precipitate was formed. The precipitate was collected and dried to yield product as a yellow solid (1.11 g, 38.58%). LC-MS: m/e 310 (MH+).

Workup

  1. customwas formed
  2. customThe precipitate was collected
  3. customdried

Sources & evidence

ORD record
ord-23662ff94fe748869fb21dfa60ee03e7
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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