Hydrochloric Acid → HCID 73198280, compound

HRID 2100746Notes

Reaction equation

HRID 2100746 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:12][CH3:13])[CH:11]=1)[C:8](=[O:14])[CH2:7][CH2:6]2.C([O:19][N:20]=O)CCC.Cl>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:12][CH3:13])[CH:11]=1)[C:8](=[O:14])[C:7](=[N:20][OH:19])[CH2:6]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10996Butyl nitriteHCID 43702075,7-Dimethoxy-indan-1-one

Product 1

HCID 73198280HCID 73198280, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of 5,7-Dimethoxy-indan-1-one (8.7 g, 45.26 mmol) in the methanol (80 ml) was added n-butylnitrite (6.13 ml, 49.78 mmol) followed by concentrated HCl (4.4 ml). The solution was stirred at 40° C. for one hour during which time a precipitate was formed. The precipitate was collected and dried to yield product as a yellow solid (10 g, 99%). LC-MS: m/e 222 (MH+).

Workup

  1. customwas formed
  2. customThe precipitate was collected
  3. customdried

Sources & evidence

ORD record
ord-356eb2a3bfd741db970fb5c55ad776de
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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