Hydrochloric Acid → HCID 76608712, compound

HRID 2100757Notes

Reaction equation

HRID 2100757 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7](=[O:12])[CH2:8][CH2:9]2)=[CH:5][C:4]=1[C:13]([NH2:15])=[O:14].C([O:20][N:21]=O)CCC.Cl>CO>[OH:20][N:21]=[C:8]1[C:7](=[O:12])[C:6]2[C:10](=[CH:11][C:3]([O:2][CH3:1])=[C:4]([C:13]([NH2:15])=[O:14])[CH:5]=2)[CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10996Butyl nitriteHCID 57799811HCID 57799811, compound

Product 1

HCID 76608712HCID 76608712, compoundYield 81.37%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 6-Methoxy-3-oxo-indan-5-carboxylic acid amide (3 g, 14.6 mmol) in the methanol (50 ml) was added n-butylnitrite (1.8 ml, 16.06 mmol), followed by concentrated HCl (1.2 ml). The solution was stirred at r.t overnight during which time a precipitate was formed. The precipitate was collected and dried to yield product as a yellow solid (2.78 g, 81.37%). LC-MS: m/e 235(MH+).

Workup

  1. customwas formed
  2. customThe precipitate was collected
  3. customdried

Sources & evidence

ORD record
ord-72cbb86188c4438aa1ee6d77223a31cc
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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