Sodium Bicarbonate → HCID 57799678, compound

HRID 2101103Notes

Reaction equation

HRID 2101103 reaction equation
CC1(C)[O:6][CH:5]([CH2:7][O:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][C:18]=2[O:19][CH2:20][CH2:21][O:22][CH3:23])[C:15]([O:24][CH:25]([CH3:27])[CH3:26])=[N:14][C:13]([NH:28][C:29]2[CH:33]=[C:32]([CH3:34])[NH:31][N:30]=2)=[CH:12]3)[CH2:4][O:3]1.C([O-])(O)=O.[Na+]>C1COCC1>[CH:25]([O:24][C:15]1[C:16]2[C:11](=[CH:10][C:9]([O:8][CH2:7][CH:5]([OH:6])[CH2:4][OH:3])=[C:18]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:17]=2)[CH:12]=[C:13]([NH:28][C:29]2[CH:33]=[C:32]([CH3:34])[NH:31][N:30]=2)[N:14]=1)([CH3:27])[CH3:26]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 57799779HCID 57799779, compound

Product 1

HCID 57799678HCID 57799678, compoundYield 18.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 30 mg of [6-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-1-isopropoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine in 5 ml THF and 1 ml 1NHCl was stirred at room temperature for 3 h, and sent to Prep. LC-MS after neutralized with NaHCO3. 5 mg of 3-[1-Isopropoxy-7-(2-methoxy-ethoxy)-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yloxy]-propane-1,2-diol was produce as solid. LC-MS: m/e 447 (MH+).

Sources & evidence

ORD record
ord-0b692a0c81ee4fadb5c13c5d001af84d
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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