HCID 57799679, compound → HCID 57799643, compound

HRID 2101127Notes

Reaction equation

HRID 2101127 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:13][CH3:14])=[C:9]([F:12])[CH:10]=2)[CH:5]=[C:4]([NH:15][C:16]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[NH:18][N:17]=2)[N:3]=1>C(O)(C)C>[CH:21]1([C:19]2[NH:18][N:17]=[C:16]([NH:15][C:4]3[N:3]=[C:2]([O:13][CH:8]([CH3:9])[CH3:7])[C:11]4[C:6]([CH:5]=3)=[CH:7][C:8]([O:13][CH3:14])=[C:9]([F:12])[CH:10]=4)[CH:20]=2)[CH2:23][CH2:22]1

Participants

3

Reactant 1

HCID 57799679HCID 57799679, compound

Product 1

HCID 57799643HCID 57799643, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Similar procedure as described in example 376 was used, starting from isopropanol, (1-Chloro-7-fluoro-6-methoxy-isoquinolin-3-yl)-(5-cyclopropyl-1H-pyrazol-3-yl)-amine to give (5-Cyclopropyl-1H-pyrazol-3-yl)-(7-fluoro-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-amine. LC-MS: m/e 357(MH+).

Sources & evidence

ORD record
ord-02704806e6344c19b91bc0a0d7fa7609
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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