4-Toluenesulfonyl chloride → 5-Bromo-2-(cyanomethyl)benzoic acid
Reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[N:12]O)[C:8]2=[O:11])=[CH:4][CH:3]=1.C1(C)C=CC(S(Cl)(=O)=[O:21])=CC=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]#[N:12])=[C:9]([CH:10]=1)[C:8]([OH:11])=[O:21]Participants
3
Procedure
Similar procedure as described in example 9B was used, starting from 6-Bromo-indan-1,2-dione 2-oxime and p-Toluenesulfonyl chloride to give 5-Bromo-2-cyanomethyl-benzoic acid. LC-MS: m/e: 238 (M−1).
Sources & evidence
- ORD record
- ord-9bb8b35719054e0a930986f4764314ab
- Source dataset
- uspto-grants-2009_08
- Patent number
- US07572809B2
Reaction notes
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