HCID 57799655, compound → HCID 23633571, compound

HRID 2101175Notes

Reaction equation

HRID 2101175 reaction equation
[C:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([O:19][CH3:20])=[C:11]([O:14][CH2:15][CH2:16][O:17][CH3:18])[CH:12]=2)[CH:7]=[C:6]([NH:21][C:22]2[CH:26]=[C:25]([CH3:27])[NH:24][N:23]=2)[N:5]=1)([CH3:3])=[CH2:2]>[Pt]>[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([O:19][CH3:20])=[C:11]([O:14][CH2:15][CH2:16][O:17][CH3:18])[CH:12]=2)[CH:7]=[C:6]([NH:21][C:22]2[CH:26]=[C:25]([CH3:27])[NH:24][N:23]=2)[N:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 57799655HCID 57799655, compound

Product 1

HCID 23633571HCID 23633571, compound

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

A mixture of [1-Isopropenyl-6-methoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine (120 mg) and 10% Pt/C (12 mg) was sealed in high-pressure bottle under 40 psi of H2 and stirred overnight at room temperature. Then the mixture was filtered and the organic layer was concentrated to give [1-Isopropyl-6-methoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: 371 (MH+).

Workup

  1. customwas sealed in high-pressure bottle under 40 psi of H2
  2. filtrationThen the mixture was filtered
  3. concentrationthe organic layer was concentrated

Sources & evidence

ORD record
ord-084a314df492414aab4341d7d73f7d2a
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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