反应详情

温度

80 °C

To a solution of 8-bromo-7-(4-chlorophenyl)-5-methyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one (42 mg, 0.124 mmol), and 3-(chloromethyl)-2-methyl-6-(trifluoromethyl)pyridine (39 mg, 0.186 mmol) in anhydrous DMF (0.5 mL) was added anhydrous potassium carbonate (34.6 mg, 0.25 mmol). The resulting suspension was stirred under argon at 80° C. for 1 h. After cooling to room temperature, the reaction mixture was diluted with water (10 mL). The resulting precipitate was filtered, washed with water, and dried in a vacuum oven at 60° C. for 16 h to afford 56 mg (89%) of the title compound as an off-white solid. HPLC/MS: retention time=4.15 min, [M+H]+=512.2.

1. temperatureAfter cooling to room temperature
2. filtrationThe resulting precipitate was filtered
3. washwashed with water
4. customdried in a vacuum oven at 60° C. for 16 h