反应详情

3,-Chloro-5-methoxy-1-phenol was dissolved in anhydrous DMF and K2CO3 was added. The reaction mixture was stirred at room temperature for 15 min and chloromethyl-1-(3,5-dichlorobenzyl)-1H-imidazole hydrochloride (see Example 1) was added to the reaction mixture. The resulting mixture was stirred at room temperature for 36 h. The mixture was diluted with FtOAc and washed with water (×2). The organic phase was dried over Na2SO4 and concentrated. The resulting residue was then purified by silica gel prep TLC using CH2Cl2:MeOH 98:2 as an eluent to afford the title compound (56 mg, 49%); MS m/z 397 [C18H15Cl3N2O2+H]+.

1. stirringThe resulting mixture was stirred at room temperature for 36 h
2. additionThe mixture was diluted with FtOAc
3. washwashed with water (×2)
4. dry with materialThe organic phase was dried over Na2SO4
5. concentrationconcentrated
6. customThe resulting residue was then purified by silica gel prep TLC