反应详情

To a solution of 2-(4-fluoro-phenoxymethyl)-1H-imidazole in DMF was added freshly ground K2CO3 followed by bromomethyl-3-chloro-5-iodo-benzene. The reaction mixture was stirred at room temperature until most of starting material was consumed. The reaction mixture was then diluted with ethyl acetate and washed with water. The organic phase was dried over MgSO4 and concentrated. The resulting residue was purified by silica gel preparative TLC using CH2Cl2:MeOH 95:5 as an eluent to afford the title compound (275 mg, 60%); MS m/z 442 [C17H13ClFIN2O+H]+.

1. customwas consumed
2. additionThe reaction mixture was then diluted with ethyl acetate
3. washwashed with water
4. dry with materialThe organic phase was dried over MgSO4
5. concentrationconcentrated
6. customThe resulting residue was purified by silica gel preparative TLC