反应详情

To a stirred solution of 3-aminobenzonitrile (4.0 g) (available from Aldrich) in ethanol (100 ml) was added hydroxylamine hydrochloride (4.7 g) and potassium carbonate (14.0 g) and the mixture heated under reflux for 22 h. After cooling to room temperature the mixture was filtered through ‘hyflo’ filter aid, the residue washed with ethanol, and the filtrates concentrated in vacuo to give the title compound as a viscous oil (5.3 g).

1. temperaturethe mixture heated
2. temperatureunder reflux for 22 h
3. filtrationwas filtered through ‘hyflo’
4. filtrationfilter aid
5. washthe residue washed with ethanol
6. concentrationthe filtrates concentrated in vacuo