N-methyl-2-pyrrolidone → 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 2101933Notes

Reaction equation

[CH3:1][N:2]1C(=O)CCC1.Cl[C:9]1[CH:14]=[CH:13][C:12]([NH:15]C(=O)C(C)(C)C)=[C:11]([C:22]#[C:23][CH3:24])[C:10]=1[C:25]([F:28])([F:27])[F:26].C([Cu])#N.[OH-].[NH4+]>CCOCC>[CH3:24][C:23]1[NH:15][C:12]2[C:11]([CH:22]=1)=[C:10]([C:25]([F:26])([F:27])[F:28])[C:9]([C:1]#[N:2])=[CH:14][CH:13]=2

Participants

Conditions

Temperature: 195 °C

Procedure

An NMP solution (150 mL) of N-[4-chloro-2-(1-propyn-1-yl)-3-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide (10 g, 31.5 mmol) was treated with CuCN (11.3 g, 126 mmol) and the resulting mixture was heated at 195° C. for 90 h. Two reactions were carried out simultaneously. The combined dark brown reaction mixture was poured into crushed ice (250 mL) containing conc. ammonium hydroxide (100 mL). The resulting slurry was stirred with the addition of Et2O and filtered through celite. The filtrate was diluted with Et2O and partitioned. The aqueous portion was extracted with Et2O four times. The combined organic portions were washed with brine and dried (MgSO4). Filtration and concentration in vacuo followed by radial chromatography (SiO2, 0-60% EtOAc-hexanes gradient) afforded the title compound as a solid (9 g, 64%): 1H NMR (400 MHz, CDCl3) δ 8.45 (s, 1H), 7.50 (d, J=9.0 Hz, 1H), 7.47 (d, J=9.0 Hz, 1H), 6.54 (s, 1H), 2.52 (s, 3H); MS (ES) m/z 225 (M+1).

Workup

additionThe combined dark brown reaction mixture was poured
filtrationfiltered through celite
additionThe filtrate was diluted with Et2O
custompartitioned
extractionThe aqueous portion was extracted with Et2O four times
washThe combined organic portions were washed with brine
dry with materialdried (MgSO4)
filtrationFiltration and concentration in vacuo

Sources & evidence

ORD record: ord-989a71022450440d9941fef716157dc7
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572820B2

Reaction notes

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