Dimethylformamide → 3-chloro-N-{[4-chloro-2-fluoro-3-(1-naphthalenyloxy)phenyl]methyl}-1H-pyrrole-2-carboxamide

HRID 210215Notes

Reaction equation

HRID 210215 reaction equation
[CH:55]([N:56]([CH:57]([CH3:58])[CH3:59])[CH2:60][CH3:61])([CH3:62])[CH3:63].[Cl:25][c:26]1[c:27]([O:35][c:36]2[cH:37][cH:38][cH:39][c:40]3[cH:41][cH:42][cH:43][cH:44][c:45]23)[c:28]([F:34])[c:29]([CH2:32][NH2:33])[cH:30][cH:31]1.[Cl:46][c:47]1[c:48]([C:52](=[O:53])[OH:54])[nH:49][cH:50][cH:51]1.[O:64]=[CH:65][N:66]([CH3:67])[CH3:68].[P-:1]([F:2])([F:3])([F:4])([F:5])([F:6])[F:7].[n:8]1([O:9][C:10]([N:11]([CH3:12])[CH3:13])=[N+:14]([CH3:15])[CH3:16])[c:17]2[n:18][cH:19][cH:20][cH:21][c:22]2[n:23][n:24]1>>[Cl:25][c:26]1[c:27]([O:35][c:36]2[cH:37][cH:38][cH:39][c:40]3[cH:41][cH:42][cH:43][cH:44][c:45]23)[c:28]([F:34])[c:29]([CH2:32][NH:33][C:52]([c:48]2[c:47]([Cl:46])[cH:51][cH:50][nH:49]2)=[O:53])[cH:30][cH:31]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 221800183-chloro-1H-pyrrole-2-carboxylic acidHCID 68486009{[4-Chloro-2-fluoro-3-(1-naphthalenyloxy)phenyl]methyl}amine

Product 1

HCID 594516343-chloro-N-{[4-chloro-2-fluoro-3-(1-naphthalenyloxy)phenyl]methyl}-1H-pyrrole-2-carboxamide

Sources & evidence

ORD record
ord-6818ac03b6334405ac491d86a3ecfe9c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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