Hydrazine hydrate (1:1) → HCID 67430484, compound

HRID 2102832Notes

Reaction equation

HRID 2102832 reaction equation
C([O:3][C:4]([C:6]1[O:7][C:8]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:9]=2[C:10]=1[NH:11][C:12](OCC)=[O:13])=O)C.O.[NH2:23][NH2:24]>C(O)C>[NH2:23][N:24]1[C:4](=[O:3])[C:6]2[O:7][C:8]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:9]=3[C:10]=2[NH:11][C:12]1=[O:13]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59535737HCID 59535737, compound

Product 1

HCID 67430484HCID 67430484, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 5-chloro-3-ethoxycarbonylamino-benzofuran-2-carboxylic acid ethyl ester (3.6 g, 11.6 mmol) in ethanol (50 mL) was added hydrazine hydrate (6.2 mL, 127 mmol). After heating at reflux for 4 h, the title compound was collected by filtration (2.9 g) and was used in the next step without further purification.

Workup

  1. temperatureAfter heating
  2. temperatureat reflux for 4 h
  3. filtrationthe title compound was collected by filtration (2.9 g)
  4. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-c1eb7a1323e642f2ba002dd70c167485
Source dataset
uspto-grants-2009_08
Patent number
US07576092B2

Reaction notes

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