反应详情

To a solution of the 7-nitro-1,2,3,4-tetrahydroquinoline (4.5 g, 25.25 mmol) in DMF (50 mL) was added potassium carbonate (15 g) followed by iodomethane (5.54 g, 39.0 mMol) and the mixture was agitated overnight at ambient temperature. The mixture was poured onto water and extracted with ether (3×200 mL). The combined ethereal extracts were washed with brine, dried and concentrated to give the crude product which was purified by column chromatography on silica-gel to obtain the title compound as an orange liquid.

1. additionThe mixture was poured onto water
2. extractionextracted with ether (3×200 mL)
3. washThe combined ethereal extracts were washed with brine
4. customdried
5. concentrationconcentrated
6. customto give the crude product which
7. customwas purified by column chromatography on silica-gel