Hydrochloric Acid → HCID 57803369, compound

HRID 2103391Notes

Reaction equation

HRID 2103391 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][CH:12]([C:15]([O:17]C)=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+].Cl>O.C1COCC1.CO>[F:19][C:2]([F:1])([F:20])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57803361HCID 57803361, compound

Product 1

HCID 57803369HCID 57803369, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Methyl 1-[3-(trifluoromethyl)phenyl]piperidine-4-carboxylate (0.9 g, 3 mmol) was treated with the mixture of 2 M of sodium hydroxide in water (10 mL), THF (10 mL) and methanol (10 mL) at 50° C. for 1 h. After being neutralized with concentrated HCl (pH=3), the solution was concentrated. The resulting residue was azeotropically treated with benzene for 3 times to give the title compound which was used for the next reaction without purification. MS (M+H) 274.1.

Workup

  1. concentrationthe solution was concentrated
  2. additionThe resulting residue was azeotropically treated with benzene for 3 times

Sources & evidence

ORD record
ord-1c28fb0303c643f69b3616267ddff326
Source dataset
uspto-grants-2009_08
Patent number
US07576089B2

Reaction notes

Loading…