反应详情

Dissolve 4-bromo-benzenethiol (2.6 g, 13.2 mmol) in 150 mL acetone, add potassium carbonate (2.0 g, 14.5 mmol) and 2-bromo-propane (1.8 g, 14.5 mmol) and stir 2 days at r.t. Evaporate the solvent under vacuum, add water and extract with dichloromethane. Filter through a hydrophobic filter paper and concentrate. Purify the resulting material via column chromatography on silica gel, eluting with hexane:ethyl acetate 98:2 to afford the title compound as a yellow oil (2.06 g). MS (m/e): 231 [(79Br)M], 233 [(81Br)M].

1. customEvaporate the solvent under vacuum
2. additionadd water
3. extractionextract with dichloromethane
4. filtrationFilter through a hydrophobic filter paper
5. concentrationconcentrate
6. customPurify the resulting material via column chromatography on silica gel
7. washeluting with hexane:ethyl acetate 98:2