反应详情

Add dimethoxymethyl-dimethyl-amine (1.05 mL, 7.66 mmol) to a solution-of 5-bromo-thiophene-2-sulfonic acid amide (1.8 g, 7.43 mmol) in DMF (3 mL) at r.t. for 16 h. Pour reaction mixture into saturated sodium chloride, extract with ethylacetate. Wash combined organic layers with water, dry over sodium sulfate and remove solvent to obtain 2.52 g product. MS (m/e): 297.0/299.0 (M+H).

1. additionPour
2. extractionextract with ethylacetate
3. washWash
4. dry with materialdry over sodium sulfate
5. customremove solvent