1-Bromo-3-chloropropane → HCID 12685614, compound

HRID 2103729Notes

Reaction equation

HRID 2103729 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.Br[CH2:11][CH2:12][CH2:13][Cl:14].C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[Cl:14][CH2:13][CH2:12][CH2:11][O:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 10796Cesium carbonateHCID 130194-Cyanophenol

Product 1

HCID 12685614HCID 12685614, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 0.47 g (0.004 mol) of 4-hydroxybenzonitrile, 0.63 g (0.004 mol) of 1-bromo-3-chloropropane and 1.95 g (0.006 mol) of caesium carbonate in 10 ml of acetonitrile is heated at reflux for 5 hours.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 5 hours

Sources & evidence

ORD record
ord-51220043849648379df5d762a6187225
Source dataset
uspto-grants-2009_08
Patent number
US07576120B2

Reaction notes

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