Dimethylformamide → 3-[8-(2,6-difluorophenyl)-2-(4-methyl-1,4'-bipiperidin-1'-yl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-(2,2,2-trifluoroethyl)benzamide

HRID 210374Notes

Reaction equation

HRID 210374 reaction equation
[CH3:67][CH2:68][N:69]([CH2:70][CH3:71])[CH2:72][CH3:73].[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:42])[cH:11][cH:12][c:13]3[c:14]2[n:15][c:16]([N:29]2[CH2:30][CH2:31][CH:32]([N:35]4[CH2:36][CH2:37][CH:38]([CH3:41])[CH2:39][CH2:40]4)[CH2:33][CH2:34]2)[n:17][c:18]3-[c:19]2[cH:20][c:21]([C:22](=[O:23])[OH:24])[cH:25][cH:26][c:27]2[CH3:28])[c:4]([F:8])[cH:5][cH:6][cH:7]1.[F:74][C:75]([CH2:76][NH2:77])([F:78])[F:79].[O:80]=[CH:81][N:82]([CH3:83])[CH3:84].[P-:43]([F:44])([F:45])([F:46])([F:47])([F:48])[F:49].[n:50]1([O:51][C:52]([N:53]([CH3:54])[CH3:55])=[N+:56]([CH3:57])[CH3:58])[c:59]2[cH:60][cH:61][cH:62][cH:63][c:64]2[n:65][n:66]1>>[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:42])[cH:11][cH:12][c:13]3[c:14]2[n:15][c:16]([N:29]2[CH2:30][CH2:31][CH:32]([N:35]4[CH2:36][CH2:37][CH:38]([CH3:41])[CH2:39][CH2:40]4)[CH2:33][CH2:34]2)[n:17][c:18]3-[c:19]2[cH:20][c:21]([C:22](=[O:23])[NH:77][CH2:76][C:75]([F:74])([F:78])[F:79])[cH:25][cH:26][c:27]2[CH3:28])[c:4]([F:8])[cH:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 9773Ethanamine, 2,2,2-trifluoro-HCID 9886HexafluorophosphateHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 57530509HCID 57530509, compound

Product 1

HCID 592127313-[8-(2,6-difluorophenyl)-2-(4-methyl-1,4'-bipiperidin-1'-yl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-(2,2,2-trifluoroethyl)benzamide

Sources & evidence

ORD record
ord-f36efc36ceb64bcaa3d740f886520b58
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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