Hydrochloric Acid → HCID 54899068, compound

HRID 2103933Notes

Reaction equation

HRID 2103933 reaction equation
[CH2:1]([NH:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7])[CH3:2].Cl.[C:10]([C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1)#[N:11]>C(Cl)Cl.CCOC(C)=O>[CH2:1]([N:3]([C:16](=[O:17])[C:15]1[CH:19]=[CH:20][C:12]([C:10]#[N:11])=[CH:13][CH:14]=1)[CH2:4][CH2:5][C:6]([OH:8])=[O:7])[CH3:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 801724-Cyanobenzoyl chlorideHCID 12227201HCID 12227201, compound

Product 1

HCID 54899068HCID 54899068, compoundYield 56%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

A suspension of ethyl β-alanine.HCl (2.81 g, 18.3 mmol) and 4-cyano-benzoyl chloride (3.03 g, 18.0 mmol) in DCM (30 mL) was stirred overnight at RT. The mixture was diluted with EtOAc, washed with aq. citric acid (3%), sat. aq. NaHCO3 and H2O. Drying (MgSO4) and evaporation of the solvent gave compound 2 (2.52 g, 56%).

Workup

  1. washwashed with aq. citric acid (3%), sat. aq. NaHCO3 and H2O
  2. customDrying
  3. custom(MgSO4) and evaporation of the solvent

Sources & evidence

ORD record
ord-13b9cac7924946a3b166279e27d831b4
Source dataset
uspto-grants-2009_08
Patent number
US07576071B2

Reaction notes

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