反应详情

温度

0 °C

To a solution of 4,6-dimethylpyrimidine (1.08 g, 10 mmol) in THF (40 ml) was added dropwise at −78° C. a solution of n-butyllithium. To the solution was added benzylbromide (1.71 g, 10 mmol). The mixture was warmed up to 0° C. and stirred for 30 minutes. To the reaction mixture was added an aqueous solution of ammonium chloride. The mixture was extracted with ethyl acetate, washed with water, dried and concentrated. The obtained residue was chromatographed on silica gel (n-hexane-ethyl acetate). The obtained fraction was concentrated to give 4-methyl-6-phenethylpyrimidine (1.7 g).

1. extractionThe mixture was extracted with ethyl acetate
2. washwashed with water
3. customdried
4. concentrationconcentrated
5. customThe obtained residue was chromatographed on silica gel (n-hexane-ethyl acetate)
6. concentrationThe obtained fraction was concentrated