Acetylacetone → HCID 11494785, compound

HRID 2104149Notes

Reaction equation

HRID 2104149 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][C:3]=1[C:15]([C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=1)=O.[C:24]([CH2:27][C:28](=O)[CH3:29])(=[O:26])[CH3:25]>C(O)(C)C>[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([C:15]2[C:3]3[C:2](=[CH:7][CH:6]=[C:5]([O:8][C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=4)[CH:4]=3)[N:1]=[C:28]([CH3:29])[C:27]=2[C:24](=[O:26])[CH3:25])=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 31261AcetylacetoneHCID 67549273HCID 67549273, compound

Product 1

HCID 11494785HCID 11494785, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

The title compound was prepared from (2-Amino-5-phenoxy-phenyl)-(4-chloro-phenyl)-methanone [example A5] and acetylacetone according to the method of example 1, except that the solvent was isopropanol, the reaction time was of 16.5 h and the residue was purified by spontaneous crystallization from the reaction mixture. Yield: 42%; MS: m/z=387 (M).

Workup

  1. customthe residue was purified by spontaneous crystallization from the reaction mixture

Sources & evidence

ORD record
ord-2485ccc67a9248d2936c696d87677569
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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