Isopropanol → HCID 11590020, compound

HRID 2104155Notes

Reaction equation

HRID 2104155 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[C:13]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)=O.[F:23][C:24]([F:32])([F:31])[C:25](=[O:30])[CH2:26][C:27](=O)[CH3:28].C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[F:23][C:24]([F:32])([F:31])[C:25]([C:26]1[C:27]([CH3:28])=[N:1][C:2]2[C:3]([C:13]=1[C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)=[CH:4][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:6][CH:7]=2)=[O:30]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 739431,1,1-Trifluoro-2,4-pentanedioneHCID 67549818HCID 67549818, compound

Product 1

HCID 11590020HCID 11590020, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from (2-Amino-5-trifluoromethoxy-phenyl)-(4-methoxy-phenyl)-methanone [example A8] and 1,1,1-trifluoro-2,4-pentanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 17 h and a grandient of heptane/ethyl acetate was used. Yield: 58%; MS: m/z=429 (M).

Sources & evidence

ORD record
ord-8a921723abd740dda3ece776547f9f64
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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