Azepane → HCID 11618848, compound

HRID 2104180Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[C:6]([C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])=[C:5]2[C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1.[NH:26]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[N:26]1([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[N:8]=[C:7]([CH3:12])[C:6]([C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])=[C:5]3[C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

Reactant 2

HCID 8119Azepane

HCID 11567771HCID 11567771, compound

Product 1

HCID 11618848HCID 11618848, compoundYield 32%

Procedure

The title compound was prepared from 1-[6-Bromo-4-(4-fluoro-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone [example 24] and azepane according to the procedure of example 25, except that the reaction time was of 16 h. Yield: 32%; MS: m/z=431 (M+H).

Sources & evidence

ORD record: ord-f685ff4631de49229cb5cb2ff5272ec7
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07576217B2

Reaction notes

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