Isopropanol → HCID 11704924, compound

HRID 2104188Notes

Reaction equation

HRID 2104188 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=1)=O.[CH:21]1([C:24](=[O:29])[CH2:25][C:26](=O)[CH3:27])[CH2:23][CH2:22]1.C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[Br:8][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[N:1]=[C:26]([CH3:27])[C:25]([C:24]([CH:21]1[CH2:23][CH2:22]1)=[O:29])=[C:9]2[C:11]1[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 110188691-Cyclopropyl-butane-1,3-dioneHCID 68405963HCID 68405963, compound

Product 1

HCID 11704924HCID 11704924, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from (2-Amino-5-bromo-phenyl)-(4-methanesulfonyl-phenyl)-methanone [example A15] and 1-cyclopropyl-1,3-butanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 16 h and heptane/ethyl acetate (1:2) was used. Yield: 47%; MS: m/z=443 (M+H).

Sources & evidence

ORD record
ord-bc7a2e69056e42b3ade1cb1c7499aac2
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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