Chloroacetyl chloride → HCID 22934835, compound

HRID 2104408Notes

Reaction equation

HRID 2104408 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[Cl:9][CH2:10][C:11](Cl)=[O:12]>C(OCC)(=O)C>[ClH:8].[Cl:9][CH2:10][C:11]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1)=[O:12]

Participants

4

Reactant 2

HCID 6577Chloroacetyl chloride2×HCID 661742-Amino-5-chloropyridine

Product 1

HCID 22934835HCID 22934835, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-Amino-5-chloropyridine (3.85 g) was dissolved in ethyl acetate (60 mL), and, at room temperature, chloroacetyl chloride (2.39 mL) was added to the solution, followed by stirring for 1 hour. After the reaction mixture was heated and stirred at 60° C. for 30 minutes, chloroacetyl chloride (0.5 mL) was additionally added, and the mixture was stirred at 60° C. for additional 1 hour. Powder precipitated was collected by filtration, to thereby give the title compound (6.18 g).

Workup

  1. temperatureAfter the reaction mixture was heated
  2. stirringstirred at 60° C. for 30 minutes
  3. stirringthe mixture was stirred at 60° C. for additional 1 hour
  4. customPowder precipitated
  5. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-859dd93c7a3041fc84cc3547bb1c3cab
Source dataset
uspto-grants-2009_08
Patent number
US07576135B2

Reaction notes

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