Diethylamine → HCID 66914259, compound

HRID 2104524Notes

Reaction equation

HRID 2104524 reaction equation
Cl[CH2:2][C:3]1[CH:38]=[CH:37][C:6]([CH2:7][O:8][C:9]2[CH:10]=[C:11]([C:15]3[C:24]4[C:19](=[C:20]([C:25]([F:28])([F:27])[F:26])[CH:21]=[CH:22][CH:23]=4)[N:18]=[CH:17][C:16]=3[C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[O:30])[CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[CH2:39]([NH:41][CH2:42][CH3:43])[CH3:40]>C(Cl)Cl>[CH2:39]([N:41]([CH2:2][C:3]1[CH:38]=[CH:37][C:6]([CH2:7][O:8][C:9]2[CH:10]=[C:11]([C:15]3[C:24]4[C:19](=[C:20]([C:25]([F:28])([F:27])[F:26])[CH:21]=[CH:22][CH:23]=4)[N:18]=[CH:17][C:16]=3[C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[O:30])[CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1)[CH2:42][CH3:43])[CH3:40]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 66913777HCID 66913777, compound

Product 1

HCID 66914259HCID 66914259, compoundYield 87.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of {4-[3-(4-chloromethyl-benzyloxy)-phenyl]-8-trifluoromethyl-quinolin-3-yl}phenyl-methanone (011 g, 0.2 mmol) and diethylamine(0.3 g, 5.7 mmol) in CH2Cl2 (5 ml) was stirred at r.t. After 24 hr, the reaction was concentrated and purified by column chromatography (eluent 25% EtOAc/Hex) to give the title compound as a foam (0.10 g); MS m/z 569.

Workup

  1. concentrationthe reaction was concentrated
  2. custompurified by column chromatography (eluent 25% EtOAc/Hex)

Sources & evidence

ORD record
ord-7c1290aeece4486bb88a06a25325854c
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

Loading…