[3-(Hydroxymethyl)phenyl]boronic acid → {3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Methanol

HRID 2104528Notes

Reaction equation

HRID 2104528 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1Br)=[CH:15][CH:14]=[CH:13][C:12]=2[C:19]([F:22])([F:21])[F:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:23][CH2:24][C:25]1[CH:26]=[C:27](B(O)O)[CH:28]=[CH:29][CH:30]=1>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:29]1[CH:30]=[C:25]([CH2:24][OH:23])[CH:26]=[CH:27][CH:28]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:19]([F:22])([F:21])[F:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2734662[3-(Hydroxymethyl)phenyl]boronic acidHCID 669131463-Benzyl-4-bromo-8-(trifluoromethyl)quinoline

Product 1

HCID 11223110{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Methanol

Procedure

This compound was prepared using the procedure of Example 1, step 5 using (3-benzyl-4-bromo-8-(trifluoromethyl)quinoline in place of [4-chloro-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone and 3-(hydroxymethyl)phenylboronic acid in place of phenyl boronic acid; MS (ES) m/z 392.5.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-3ffb794679574ba8b85a3ea9214dfdf7
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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