反应详情

温度

50 °C

To a solution of Intermediate 7.1 (assumed 24.3 mmol) in 50 mL DMF, was added K2CO3 (4.03 g, 29.2 mmol) and 2-iodopropane (4.86 mL, 48.6 mmol). The mixture was stirred at 50° C. for 16 h, then was diluted with EtOAc/hexanes (1:1). The organic phase was washed with H2O (3×) and brine, dried (Na2SO4) and concentrated. The crude product was purified by flash chromatography (0 to 30% EtOAc/hexanes gradient) to afford 3.94 g of Intermediate 7.2 as a white solid.

1. washThe organic phase was washed with H2O (3×) and brine
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated
4. customThe crude product was purified by flash chromatography (0 to 30% EtOAc/hexanes gradient)