反应详情

温度

0 °C

To a solution of Intermediate 122.1 (50 mg, 0.06 mmol) in THF (1 mL) was added EtMgBr dropwise at 0° C. under N2 atmosphere, the reaction mixture was stirred at 0° C. for 30 min. The reaction mixture was then partionated between EtOAc and sat. NaCl, the organic layer was collected and dried over (Na2SO4), filtered and concentrated. The crude material Intermediate 122.2 was used as is in the following step. LCMS (2 min gradient) RT=2.23 min, 828.4 (M+H).

1. customthe organic layer was collected
2. dry with materialdried over (Na2SO4)
3. filtrationfiltered
4. concentrationconcentrated
5. customLCMS (2 min gradient) RT=2.23 min, 828.4 (M+H)