4-Aminobenzonitrile → HCID 178436565, compound

HRID 2105014Notes

Reaction equation

HRID 2105014 reaction equation
C(OC1C=C(C=CC=1OC(C)C)/C=[N:8]/[C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)C.[Si:24]([O:31][C:32]1[C:33]([F:42])=[C:34]([CH:37]=[C:38]([CH2:40][CH3:41])[CH:39]=1)[CH:35]=O)([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25].NC1C=CC(C#N)=CC=1>>[Si:24]([O:31][C:32]1[C:33]([F:42])=[C:34]([CH:37]=[C:38]([CH2:40][CH3:41])[CH:39]=1)/[CH:35]=[N:8]/[C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25]

Participants

4

Reactant 3

HCID 133964-AminobenzonitrileHCID 598380723-{[tert-Butyl(dimethyl)silyl]oxy}-5-ethyl-2-fluorobenzaldehydeHCID 178466719HCID 178466719, compound

Product 1

HCID 178436565HCID 178436565, compound

Procedure

According to the procedure for Intermediate 1.1, Intermediate 188.3 (3.72 g, 13.17 mmol) and 4-aminobenzonitrile (1.56 g, 13.17 mmol) afforded 5.10 g of Intermediate 188.4 as an orange oil.

Sources & evidence

ORD record
ord-d9d500eb11584bd18996fa30d720609e
Source dataset
uspto-grants-2009_08
Patent number
US07576098B2

Reaction notes

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