4-Aminobenzonitrile → 4-(5-Ethyl-2-fluorostyryl)benzonitrile

HRID 2105038Notes

Reaction equation

C(OC1C=C(C=CC=1OC(C)C)/C=N/[C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)C.[CH2:24]([C:26]1[CH:27]=[CH:28][C:29]([F:34])=[C:30]([CH:33]=1)[CH:31]=O)[CH3:25].N[C:36]1C=CC(C#N)=CC=1>>[CH2:24]([C:26]1[CH:27]=[CH:28][C:29]([F:34])=[C:30]([CH:33]=1)[CH:31]=[CH:36][C:9]1[CH:10]=[CH:11][C:12]([C:13]#[N:14])=[CH:15][CH:16]=1)[CH3:25]

Participants

Reactant 3

HCID 133964-Aminobenzonitrile

HCID 578038035-Ethyl-2-fluorobenzaldehyde

HCID 178466719HCID 178466719, compound

Product 1

HCID 688172594-(5-Ethyl-2-fluorostyryl)benzonitrile

Procedure

According to procedure for the preparation of Intermediate 1.1, 5-ethyl-2-fluorobenzaldehyde (900 mg, 5.88 mmol) and 4-aminobenzonitrile (694 mg, 5.88 mmol) afforded 950 mg of Intermediate 262.1

Sources & evidence

ORD record: ord-67bc6287cdcf4d958bc14483b1ea3fae
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07576098B2

Reaction notes

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