Sodium hydride → HCID 16679026, compound

HRID 2105422Notes

Reaction equation

HRID 2105422 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:18]=[CH:17][C:16]3[N:15]4[CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:24])[C:14]4=[CH:13][C:12]=3[CH:11]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:25][O:26][CH2:27][CH2:28]Br.[H-].[Na+]>>[CH3:25][O:26][CH2:27][CH2:28][N:22]1[CH2:21][CH2:20][CH2:19][N:15]2[C:16]3[CH:17]=[CH:18][C:10]([O:9][CH2:8][CH2:7][CH2:6][N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)=[CH:11][C:12]=3[CH:13]=[C:14]2[C:23]1=[O:24]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 809722-Bromoethyl methyl etherHCID 16679702HCID 16679702, compound

Product 1

HCID 16679026HCID 16679026, compoundYield 15%

Procedure

The title compound was synthesized in analogy to example 17, from 9-(3-pyrrolidin-1-yl-propoxy)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one (example 16), 2-bromoethyl methyl ether and sodium hydride, to give the desired product as a colorless oil (15%).

Sources & evidence

ORD record
ord-76e7857ced4b4e1090c6a9e1f9787709
Source dataset
uspto-grants-2009_08
Patent number
US07579351B2

Reaction notes

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