反应详情

The solution of 1-(4-methylphenyl)-2-phenylethanone (2-1) (Renault, O; Dallemagne, P.; and Rault, S. Org. Prep. Proced. Int. 1999, 31, 324) (3.29 g, 15.65 mmol) and N,N-dimethylformamide dimethylacetal (4.66 g, 39.12 mmol) in DMF (15 mL) was stirred at 110° C. for 1 h. The mixture was concentrated in vacuo to give 3-(dimethylamino)-1-(4-methylphenyl)-2-phenylprop-2-en-1-one (2-2. LRMS m/z (M+H) Calcd: 266.4, found: 266.2.

1. concentrationThe mixture was concentrated in vacuo