Phenethylamine → HCID 58998972, compound

HRID 2105771Notes

Reaction equation

C[O:2][C:3](=O)[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([F:20])[CH:14]=1)=O.[CH2:21]([NH2:29])[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[F:30][C:31]([F:36])([F:35])[CH2:32][CH2:33][NH2:34]>>[F:30][C:31]([F:36])([F:35])[CH2:32][CH2:33][NH:34][C:3]([C:4]1[CH:10]=[C:11]([C:13]2[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([F:20])[CH:14]=2)[N:29]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:5]=1[CH3:6])=[O:2]

Participants

Reactant 4

HCID 1001Phenethylamine

HCID 7757Methyl acetoacetate

HCID 100013,3,3-Trifluoropropylamine

HCID 27783312-Bromo-1-(3,5-difluorophenyl)ethanone

Product 1

HCID 58998972HCID 58998972, compound

Procedure

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(3,5-difluoro-phenyl)-ethanone as compound of formula S, phenethylamine as R3—(CH2)m—NH2 and 3,3,3-trifluoro-N-propylamine as R1R2NH, MS (ISP) 437.2 (M+H)+.

Sources & evidence

ORD record: ord-36363c4a3b90462dac21dfd298188018
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579369B2

Reaction notes

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