Potassium Carbonate → HCID 68814252, compound

HRID 2105946Notes

Reaction equation

HRID 2105946 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.C(=O)([O-])[O-:16].[K+].[K+].[F:21][C:22]([F:27])([F:26])[CH2:23][CH2:24]I>C(#N)C>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1([OH:16])[CH2:14][CH2:13][N:12]([CH2:24][CH2:23][C:22]([F:27])([F:26])[F:21])[CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1561651,1,1-Trifluoro-3-iodopropaneHCID 17895683HCID 17895683, compound

Product 1

HCID 68814252HCID 68814252, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 2: 4-(2,3-dichlorophenyl)piperidine (0.02 g, 0.081 mmol), acetonitrile (2 ml), potassium carbonate (0.02 g, 0.14 mmol), 1,1,1-trifluoro-3-iodopropane (0.010 ml, 0.082 mmol). MS m/z (relative intensity, 70 eV) 343 (M+, 10), 341 (M+, 15), 260 (52), 258 (82), 152 (54), 42 (bp).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-8e464007f66545e2b5c8fcc9a4b1f9a7
Source dataset
uspto-grants-2009_08
Patent number
US07579474B2

Reaction notes

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