Trifluoroacetic acid → HCID 23149867, compound

HRID 2105949Notes

Reaction equation

HRID 2105949 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:21])[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:22]([F:25])([F:24])[F:23].FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:21])[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[CH:4][C:3]=1[C:22]([F:24])([F:23])[F:25]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68815751HCID 68815751, compound

Product 1

HCID 23149867HCID 23149867, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

According to Preparation 2: Tert-butyl 4-[4-methyl-3-(trifluoro-methyl)phenyl]-4-hydroxypiperidine-1-carboxylate (5.5 g, 15.3 mmol, methylen chloride (30 ml), trifluoroacetic acid (4.5 ml). Yield: 1.97 g. MS m/z (rel. intensity, 70 eV) 259 (M+, 14), 241 (84), 240 (43), 187 (19), 56 (bp).

Workup

  1. customAccording to Preparation 2

Sources & evidence

ORD record
ord-69926036db2844adac393e3324bdd5d4
Source dataset
uspto-grants-2009_08
Patent number
US07579474B2

Reaction notes

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