Trifluoroacetic acid → 4-(2,3-Dichlorophenyl)piperidin-4-ol

HRID 2105952Notes

Reaction equation

HRID 2105952 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1([OH:22])[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1([OH:22])[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57438798HCID 57438798, compound

Product 1

HCID 627881684-(2,3-Dichlorophenyl)piperidin-4-ol

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

According to Preparation 2: Tert-butyl 4-(2,3-dichlorophenyl)-4-hydroxypiperidine-1-carboxylate (3.0 g, 8.7 mmol), methylen chloride (50 ml), trifluoroacetic acid (10 ml). Yield: 0.88 g. MS m/z (rel. intensity, 70 eV) 246 (M+, 8), 245 (14), 212 (34), 210 (bp), 192 (67).

Workup

  1. customAccording to Preparation 2

Sources & evidence

ORD record
ord-c6ed9083b342441c8587a824ea462a2d
Source dataset
uspto-grants-2009_08
Patent number
US07579474B2

Reaction notes

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