Potassium Carbonate → HCID 57810545, compound

HRID 2106442Notes

Reaction equation

HRID 2106442 reaction equation
[CH2:1]([O:8][C:9]1[CH:30]=[CH:29][C:12]2[CH:13]=[C:14]([C:16]([C:21]3[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([CH3:28])[CH:22]=3)([CH2:19][CH3:20])[CH2:17][CH3:18])[O:15][C:11]=2[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:32][C:33](=[O:38])[C:34]([CH3:37])([CH3:36])[CH3:35].C([O-])([O-])=O.[K+].[K+]>>[CH2:1]([O:8][C:9]1[CH:30]=[CH:29][C:12]2[CH:13]=[C:14]([C:16]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH2:32][C:33](=[O:38])[C:34]([CH3:37])([CH3:36])[CH3:35])=[C:23]([CH3:28])[CH:22]=3)([CH2:19][CH3:20])[CH2:17][CH3:18])[O:15][C:11]=2[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 21642BromopinacoloneHCID 57810583HCID 57810583, compound

Product 1

HCID 57810545HCID 57810545, compoundYield 86.4%

Procedure

4-[1-(6-Benzyloxy-benzofuran-2-yl)-1-ethyl-propyl]-2-methyl-phenol (5.50 g, 13.7 mmol) and 1-bromopinacolone (4.92 g, 27.5 mmol) and K2CO3 (3.80 g, 27.5 mmol) are reacted analogous to Example 1E to give the title compound as a pale yellow oil (5.90 g, 86%).

Sources & evidence

ORD record
ord-3592e0f9f51b40e298560db1d108dbac
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

Loading…