Potassium Carbonate → HCID 57810586, compound

HRID 2106461Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:15]=[CH:14][C:13]([C:16]([CH2:27][CH3:28])([C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[C:21]([CH3:26])[CH:20]=3)[CH2:17][CH3:18])=[CH:12][C:9]=2[C:10]=1[CH3:11])=[O:5])[CH3:2].Br[CH2:30][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33].C([O-])([O-])=O.[K+].[K+]>>[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:15]=[CH:14][C:13]([C:16]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH2:30][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33])=[C:21]([CH3:26])[CH:20]=3)([CH2:27][CH3:28])[CH2:17][CH3:18])=[CH:12][C:9]=2[C:10]=1[CH3:11])=[O:5])[CH3:2]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 21642Bromopinacolone

HCID 57810544HCID 57810544, compound

Product 1

HCID 57810586HCID 57810586, compoundYield 94%

Procedure

5-[1-Ethyl-1-(4-hydroxy-3-methyl-phenyl)-propyl]-3-methyl-benzofuran-2-carboxylic acid ethyl ester (4.04 g, 10.6 mmol) and 1-bromopinacolone (2.66 g, 14.9 mmol) and K2CO3 (2.91 g, 21.2 mmol) are reacted analogous to Example 1E to give the title compound as a pale yellow oil (4.77 g, 94%).

Sources & evidence

ORD record: ord-830d38c09a8b4dd2bf03bf2dcea3252e
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579488B2

Reaction notes

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