Sodium borohydride → HCID 85429906, compound

HRID 2106471Notes

Reaction equation

HRID 2106471 reaction equation
[CH3:1][C:2]([CH3:37])([CH3:36])[C:3](=[O:35])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:17]2[CH:18]=[CH:19][C:20]3[O:24][C:23]([C:25]([N:27]([CH2:29][C:30]([OH:32])=[O:31])[CH3:28])=[O:26])=[CH:22][C:21]=3[CH:33]=2)([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:8][C:7]=1[CH3:34].[BH4-].[Na+]>C1COCC1>[CH2:13]([C:12]([C:17]1[CH:18]=[CH:19][C:20]2[O:24][C:23]([C:25]([N:27]([CH2:29][C:30]([OH:32])=[O:31])[CH3:28])=[O:26])=[CH:22][C:21]=2[CH:33]=1)([C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH:3]([OH:35])[C:2]([CH3:36])([CH3:37])[CH3:1])=[C:7]([CH3:34])[CH:8]=1)[CH2:15][CH3:16])[CH3:14]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 11352691HCID 11352691, compound

Product 1

HCID 85429906HCID 85429906, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

[(5-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-benzofuran-2-carbonyl)-methyl-amino]-acetic acid (130 mg, 0.256 mmol) in THF (2.0 mL) are reacted with NaBH4 (19 mg, 0.513 mmol) analogous to Example 8 to yield title compound (120 mg, 92%). MS (ES) m/e: 508.3 (M−1), 510.3 (M+1)

Sources & evidence

ORD record
ord-99c52658f13246f4951f5f8ee96d2ca8
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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