Potassium Carbonate → HCID 57810560, compound

HRID 2106477Notes

Reaction equation

HRID 2106477 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]2[O:16][C:15]([C:17]([C:22]3[CH:27]=[CH:26][C:25]([OH:28])=[C:24]([CH3:29])[CH:23]=3)([CH2:20][CH3:21])[CH2:18][CH3:19])=[CH:14][C:13]=2[CH:30]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:32][C:33](=[O:38])[C:34]([CH3:37])([CH3:36])[CH3:35].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]2[O:16][C:15]([C:17]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH2:32][C:33](=[O:38])[C:34]([CH3:37])([CH3:36])[CH3:35])=[C:24]([CH3:29])[CH:23]=3)([CH2:20][CH3:21])[CH2:18][CH3:19])=[CH:14][C:13]=2[CH:30]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 21642BromopinacoloneHCID 57810580HCID 57810580, compound

Product 1

HCID 57810560HCID 57810560, compoundYield 63.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-[1-(5-Benzyloxy-benzofuran-2-yl)-1-ethyl-propyl]-2-methyl-phenol (4.05 g, 10.1 mmol) and 1-bromopinacolone (2.17 g, 12.1 mmol) and K2CO3 (2.79 g, 20.2 mmol) in acetone (50 mL) are reacted analogous to Example 18-E to give the title compound (3.20 g, 63%).

Sources & evidence

ORD record
ord-32e2a242e8f4419990aa6fd8ac8ebe28
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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