Triethylamine → HCID 57810573, compound

HRID 2106479Notes

Reaction equation

[CH2:1]([C:3]([C:16]1[CH:29]=[CH:28][C:19]([O:20][CH2:21][C:22](=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24])=[C:18]([CH3:30])[CH:17]=1)([C:6]1[O:7][C:8]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][C:9]=2[CH:10]=1)[CH2:4][CH3:5])[CH3:2].[CH3:31][S:32](Cl)(=[O:34])=[O:33].CCN(CC)CC>C(Cl)Cl>[CH3:26][C:23]([CH3:25])([CH3:24])[C:22](=[O:27])[CH2:21][O:20][C:19]1[CH:28]=[CH:29][C:16]([C:3]([C:6]2[O:7][C:8]3[CH:14]=[CH:13][C:12]([O:15][S:32]([CH3:31])(=[O:34])=[O:33])=[CH:11][C:9]=3[CH:10]=2)([CH2:4][CH3:5])[CH2:1][CH3:2])=[CH:17][C:18]=1[CH3:30]

Participants

Conditions

Temperature: 0 °C

Procedure

A solution of 1-{4-[1-ethyl-1-(5-hydroxy-benzofuran-2-yl)-propyl]-2-methyl-phenoxy}-3,3-dimethyl-butan-2-one (236 mg, 0.579 mmol) in CH2Cl2 (10 mL) was treated with methanesulfonic chloride (99 mg, 0.868 mmol) and Et3N (0.40 mL). The mixture was stirred at 0° C. for 30 min, and the reaction is quenched with MeOH (1.0 mL). The mixture is purified with EtOAc/Hexanes (25%) to obtain the title compound (260 mg, 92%). MS (ES) m/e: 504.2 (M+18).

Workup

customthe reaction is quenched with MeOH (1.0 mL)
customThe mixture is purified with EtOAc/Hexanes (25%)

Sources & evidence

ORD record: ord-406d759c134b42a6ba0e81b3f260922f
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579488B2

Reaction notes

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