Potassium Carbonate → HCID 57810536, compound

HRID 2106485Notes

Reaction equation

HRID 2106485 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:14]=[C:13]([C:15]([CH2:26][CH3:27])([C:18]3[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([CH3:25])[CH:19]=3)[CH2:16][CH3:17])[CH:12]=[CH:11][C:9]=2[CH:10]=1)=[O:5])[CH3:2].Br[CH2:29][C:30](=[O:35])[C:31]([CH3:34])([CH3:33])[CH3:32].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:14]=[C:13]([C:15]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH2:29][C:30](=[O:35])[C:31]([CH3:34])([CH3:33])[CH3:32])=[C:20]([CH3:25])[CH:19]=3)([CH2:26][CH3:27])[CH2:16][CH3:17])[CH:12]=[CH:11][C:9]=2[CH:10]=1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 21642BromopinacoloneHCID 57810538HCID 57810538, compound

Product 1

HCID 57810536HCID 57810536, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

6-[1-Ethyl-1-(4-hydroxy-3-methyl-phenyl)-propyl]-benzofuran-2-carboxylic acid ethyl ester (1.58 g, 4.31 mmol) and 1-bromopinacolone (1.16 g, 6.47 mmol) and K2CO3 (1.78 g, 12.9 mmol) in acetone (50 mL) are reacted analogous to Example 30-D to give the title compound (1.80 g, 90%).

Sources & evidence

ORD record
ord-d7c62f38182a4a11860d2d1c03b177fb
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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