Methanol → HCID 11293500, compound

HRID 2106486Notes

Reaction equation

HRID 2106486 reaction equation
C([O:3][C:4]([C:6]1[O:7][C:8]2[CH:14]=[C:13]([C:15]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH2:27][C:28](=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30])=[C:22]([CH3:34])[CH:21]=3)([CH2:18][CH3:19])[CH2:16][CH3:17])[CH:12]=[CH:11][C:9]=2[CH:10]=1)=[O:5])C.[OH-].[Na+].CO>C1COCC1>[CH3:32][C:29]([CH3:30])([CH3:31])[C:28](=[O:33])[CH2:27][O:26][C:23]1[CH:24]=[CH:25][C:20]([C:15]([C:13]2[CH:12]=[CH:11][C:9]3[CH:10]=[C:6]([C:4]([OH:5])=[O:3])[O:7][C:8]=3[CH:14]=2)([CH2:18][CH3:19])[CH2:16][CH3:17])=[CH:21][C:22]=1[CH3:34]

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 57810536HCID 57810536, compound

Product 1

HCID 11293500HCID 11293500, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-benzofuran-2-carboxylic acid ethyl ester (980 mg, 2.11 mmol) and NaOH (2 N, 10.0 mL) and MeOH (5.0 mL) and THF (5.0 mL) are reacted analogous to Example 2 to give the title compound (880 mg, 96%). MS (ES) m/e: 435.3 (M−1).

Sources & evidence

ORD record
ord-6f4127eea532453bbf4ddf61fd425a3d
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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